How quickly does Hylase dissolve filler?

Most of the filler breaks down within 24 hours. Complete dissolution takes 24 to 48 hours. Larger volumes or more cross-linked filler may need a second session after 1 to 2 weeks.

Is dissolution with hyaluronidase safe?

Yes, but allergy testing is always done before the first treatment. Allergic reaction is uncommon but possible. Hyaluronidase is an approved medication and requires a licensed prescriber.

Can Hylase dissolve Sculptra or Radiesse?

No. Hyaluronidase only acts on hyaluronic acid. Sculptra (PLLA), Radiesse (CaHA), polynucleotides, and other biostimulators cannot be dissolved enzymatically — they break down naturally over 12 to 25 months.

Will my own hyaluronic acid be affected?

Temporarily, yes. The enzyme also affects the body's own hyaluronic acid in the area, which can cause mild volume loss and short-term skin dryness for 1 to 2 weeks. The effect is reversible.

Can I get new filler after Hylase?

Yes, but wait at least 2 weeks so the enzyme has cleared the tissue. Otherwise the new filler may start breaking down prematurely.

Hyaluronidase: glossary | Dibélle

Also known as: Hylase, hyaluronidase, Hyalase, Hylenex

What is hyaluronidase?

Hyaluronidase is an enzyme that breaks down hyaluronic acid. It occurs naturally in connective tissue, tears, and seminal fluid, but for medical use it is produced recombinantly or purified from sheep or bovine sources. The most common brand in Sweden is Hylase. The substance is approved as a medication and requires a licensed prescriber.

How it works in treatment

Hyaluronidase cleaves the glycosidic bonds in the hyaluronic acid chain. Within 24 to 48 hours the injected filler breaks down into smaller fragments that the body absorbs. Dosing is governed by the amount of filler, the cross-linking type, and the area treated. More cross-linked filler requires a higher dose.

Where it is used

At Dibélle, hyaluronidase is used in three situations. First: planned dissolution of filler that has not given the desired result (unwanted shape, asymmetry, migration). Second: acute intervention against vascular occlusion — a rare but serious complication where filler compresses a vessel. Third: correction of filler placed by another injector before new treatment is started.

Results and safety

Dissolution takes 24 to 48 hours. Allergic reaction is the main safety concern — every patient is tested before the first treatment. Hyaluronidase only affects hyaluronic acid, not CaHA, PLLA, polynucleotides, or other biostimulators. The substance also temporarily affects the body's own hyaluronic acid around the injection site, which can give mild volume loss for 1-2 weeks.

Common questions about Hyaluronidase

How quickly does Hylase dissolve filler?: Most of the filler breaks down within 24 hours. Complete dissolution takes 24 to 48 hours. Larger volumes or more cross-linked filler may need a second session after 1 to 2 weeks.
Is dissolution with hyaluronidase safe?: Yes, but allergy testing is always done before the first treatment. Allergic reaction is uncommon but possible. Hyaluronidase is an approved medication and requires a licensed prescriber.
Can Hylase dissolve Sculptra or Radiesse?: No. Hyaluronidase only acts on hyaluronic acid. Sculptra (PLLA), Radiesse (CaHA), polynucleotides, and other biostimulators cannot be dissolved enzymatically — they break down naturally over 12 to 25 months.
Will my own hyaluronic acid be affected?: Temporarily, yes. The enzyme also affects the body's own hyaluronic acid in the area, which can cause mild volume loss and short-term skin dryness for 1 to 2 weeks. The effect is reversible.
Can I get new filler after Hylase?: Yes, but wait at least 2 weeks so the enzyme has cleared the tissue. Otherwise the new filler may start breaking down prematurely.

Hyaluronidase