What is the difference between Polyphil and Sculptra?

Both are synthetic biostimulators. Polyphil contains PCL (polycaprolactone) with longer durability (24-36 months) and softer structure. Sculptra contains PLLA (poly-L-lactic acid) with 9-12 months breakdown but 25-month final result. Polyphil gives initial volume; Sculptra does not.

How long does Polyphil last?

Results last 18-36 months depending on product version and area. Polyphil Next lasts longer than Polyphil Eye and Hair because the microspheres are larger and break down more slowly.

Polyphil Hair for hair loss — does it work?

Polyphil Hair stimulates dermal papilla cells (where the hair follicle sits) through the combination of mechanical irritation from microspheres and collagen build-up in the sub-galeal tissue. The result is often synergistic with PRP or pharmaceutical treatment.

Can Polyphil be dissolved?

No, PCL cannot be dissolved enzymatically like hyaluronic acid. The substance breaks down naturally over 24-36 months. Correct placement at the time of injection is therefore critical.

Polyphil: glossary | Dibélle

Also known as: Polyphil Next, Polyphil Hair, Polyphil Eye

What is Polyphil?

Polyphil is made by Italian Promoitalia, the same company that produces Nucleofill. The active substance is polycaprolactone (PCL) — a bioresorbable polymer in microsphere form suspended in HA carrier. PCL has been used in medical implants since the 1970s.

How Polyphil works

The HA carrier gives initial volume on injection. The PCL microspheres signal fibroblasts to build type I and III collagen over 6-12 months. As the HA absorbs, the collagen carries the volume. Polyphil versions vary in particle size and concentration tailored to different areas.

Polyphil at Dibélle

At Dibélle, the Polyphil line is used for broad-scale skin tightening on the face (Polyphil), scalp stimulation (Polyphil Hair), and periorbital skin (Polyphil Eye). Treatment is given as a course of 1-2 sessions with follow-up as needed.

Results and safety

Initial volume fades over a few weeks as the HA carrier absorbs — then collagen build-up takes over. The final result lasts 18-36 months. Polyphil cannot be dissolved. Correct depth and technique are critical.

Common questions about Polyphil

What is the difference between Polyphil and Sculptra?: Both are synthetic biostimulators. Polyphil contains PCL (polycaprolactone) with longer durability (24-36 months) and softer structure. Sculptra contains PLLA (poly-L-lactic acid) with 9-12 months breakdown but 25-month final result. Polyphil gives initial volume; Sculptra does not.
How long does Polyphil last?: Results last 18-36 months depending on product version and area. Polyphil Next lasts longer than Polyphil Eye and Hair because the microspheres are larger and break down more slowly.
Polyphil Hair for hair loss — does it work?: Polyphil Hair stimulates dermal papilla cells (where the hair follicle sits) through the combination of mechanical irritation from microspheres and collagen build-up in the sub-galeal tissue. The result is often synergistic with PRP or pharmaceutical treatment.
Can Polyphil be dissolved?: No, PCL cannot be dissolved enzymatically like hyaluronic acid. The substance breaks down naturally over 24-36 months. Correct placement at the time of injection is therefore critical.

Polyphil